Lizzo, Billie Eilish and Sir Elton John will perform at a TV concert curated by Lady Gaga, which will celebrate health workers amid the coronavirus crisis.
Gaga, along with the group Global Citizen, has already raised $35m (£28m) for the World Health Organisation.
The funds will buy protective equipment for health workers and support efforts to develop drugs and vaccines.
Gaga also announced she had co-curated a concert to recognise health workers’ efforts in fighting Covid-19.
One World: Together at Home, which will also feature Sir Paul McCartney and Stevie Wonder, will be live-streamed in the US and screened on BBC One in the UK.
Speaking at a press conference on Monday, Gaga said she wanted to stress the “deep gratitude” she and many others felt towards the medical community for their work in fighting the coronavirus pandemic.
“My heart is very achy and warm for those who are ER doctors as well as nurses who are sleeping in cars to make sure they don’t infect their families or their patients,” said the singer, whose real name is Stefani Germanotta.
“What you are doing is putting yourself in harm’s way to help the world and we all salute you.”
She continued: “What’s very important is three things happening for all of us. That we celebrate and we highlight the singular kind global community that is arising right now.
“Two, we want to highlight the gravity of this historical, unprecedented cultural movement. And three, we want to celebrate and encourage the power of the human spirit.”
Hosted by US talk show hosts Jimmy Fallon, Jimmy Kimmel and Stephen Colbert, One World: Together at Home will go out on 18 April across TV networks in the US.
It will also be streamed on social media platforms including YouTube.
Given the current guidelines on social distancing, performers will appear remotely, but full details of the logistics have not yet been announced.
Other celebrities expected to appear include David Beckham, John Legend, Kerry Washington, Priyanka Chopra Jonas, Shah Rukh Khan and Sesame Street cast members and Idris and Sabrina Elba, who both previously tested positive for Covid-19.
